Open Access<p>Intermedin Alleviates Renal Ischemia-Reperfusion Injury and Enhances Neovascularization in Wistar Rats</p>
Author(s) -
Yanhong Wang,
Yang Mi,
Jing Tian,
Xi Qiao,
Xiaole Su,
Jian Kang,
Zhijing Wu,
Guiqing Wang,
Xiaoshuang Zhou,
Yun Zhou,
Rongshan Li
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s253019
Subject(s) - medicine , angiogenesis , renal ischemia , ischemia , kidney , reperfusion injury , kidney disease , mmp2 , renal function , neovascularization , creatinine , endocrinology , pathology , cancer , metastasis
Ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI) and increases the risk of subsequently developing chronic kidney disease. Angiogenesis has been shown to play an important role in reducing renal injury after ischemia reperfusion. In this study, we investigated whether IMD could reduce renal IRI by promoting angiogenesis.