Open Access<p>Leflunomide Inhibits Proliferation and Induces Apoptosis via Suppressing Autophagy and PI3K/Akt Signaling Pathway in Human Bladder Cancer Cells</p>
Author(s) -
Li Cheng,
Hao Wang,
Zicheng Wang,
Houbao Huang,
Zhuo Dong,
Jian Lin
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s252626
Subject(s) - autophagy , leflunomide , pi3k/akt/mtor pathway , protein kinase b , apoptosis , cancer research , viability assay , bladder cancer , cell cycle checkpoint , cell cycle , cell growth , cancer cell , cancer , medicine , pharmacology , chemistry , immunology , biochemistry , methotrexate
Bladder cancer is a lethal human malignancy. Currently, treatment for bladder cancer is limited. The anti-tumor effects of leflunomide have attracted much more concern in multiple human cancers.