Open Access<p>Cordycepin Inhibits Human Gestational Choriocarcinoma Cell Growth by Disrupting Centrosome Homeostasis</p>
Author(s) -
ChiaYih Wang,
Shih Wei Tsai,
Han Hsiang Chien,
Ting Yu Chen,
Shi Yuan Sheu,
Edmund Cheung So,
Bu Miin Huang
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s252401
Subject(s) - cordycepin , microbiology and biotechnology , cell growth , centrosome , apoptosis , biology , cell cycle , choriocarcinoma , programmed cell death , chemistry , cancer research , biochemistry , genetics
Human gestational choriocarcinoma, a type of gestational trophoblastic disease, occurs after miscarriage, abortion, ectopic pregnancy, or molar pregnancy. Despite recent advances in the mechanism of anticancer drugs that induce human gestational choriocarcinoma apoptosis or block its growth, new therapeutic approaches are needed to be established. Cordycepin is an active anti-cancer component extracted from Cordyceps sinensis . It prevents cell proliferation both in vitro and in vivo.