Open Access<p>Leonurine Promotes Cisplatin Sensitivity in Human Cervical Cancer Cells Through Increasing Apoptosis and Inhibiting Drug-Resistant Proteins</p>
Author(s) -
Min Lin,
Chunyu Pan,
Wenbin Xu,
Jingwei Li,
Xueqiong Zhu
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s252112
Subject(s) - cisplatin , apoptosis , cancer research , flow cytometry , cell growth , cell cycle , cancer cell , mtt assay , cell , cancer , chemotherapy , medicine , chemistry , immunology , biochemistry
Cisplatin-based neoadjuvant chemotherapy and concurrent radiotherapy and chemotherapy are the main treatment for advanced cervical cancer. However, the development of multidrug resistance (MDR) leads to chemotherapy failure, tumor recurrence and poor survival. In this research, we investigated the effect and corresponding mechanism of leonurine on cisplatin sensitivity of cervical cancer cells.