Open Access<p>Epigallocatechin-3-Gallate Protects H<sub>2</sub>O<sub>2</sub>-Induced Nucleus Pulposus Cell Apoptosis and Inflammation by Inhibiting cGAS/Sting/NLRP3 Activation</p>
Author(s) -
Yixing Tian,
Zhaohua Bao,
Yiming Ji,
Xin Mei,
Huilin Yang
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s251623
Subject(s) - apoptosis , viability assay , western blot , cell cycle , flow cytometry , sting , microbiology and biotechnology , medicine , cancer research , chemistry , immunology , biology , biochemistry , engineering , gene , aerospace engineering
Intervertebral disc degeneration (IDD) is the most common diagnosis of patients with lower back pain. IDD is the underlying lesion of many spinal degenerative diseases; however, the role of cGAS/Sting/NLRP3 pathway and epigallocatechin gallate (EGCG) in the development of IDD remained unclear.