Open Access<p>Nano-Graphene Oxide-supported APTES-Spermine, as Gene Delivery System, for Transfection of pEGFP-p53 into Breast Cancer Cell Lines</p>
Author(s) -
Vida Mirzaie,
Mehdi Ansari,
Seyed Noureddin Nematollahi-Mahani,
Mahshid Moballegh Nasery,
Behzad Karimi,
Touba Eslaminejad,
Yaghoub Pourshojaei
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s251005
Subject(s) - transfection , spermine , gene delivery , graphene , oxide , gene , chemistry , microbiology and biotechnology , polymer , biophysics , nanoparticle , materials science , nuclear chemistry , nanotechnology , biochemistry , biology , organic chemistry , enzyme
Genetic diseases can be the result of genetic dysfunctions that happen due to some inhibitory and/or environmental risk factors, which are mostly called mutations. One of the most promising treatments for these diseases is correcting the faulty gene. Gene delivery systems are an important issue in improving the gene therapy efficiency. Therefore, the main purpose of this study was modifying graphene oxide nanoparticles by spermine in order to optimize the gene delivery system.