Open Access<p>Berberine Attenuates Arterial Plaque Formation in Atherosclerotic Rats with Damp-Heat Syndrome via Regulating Autophagy</p>
Author(s) -
Ke Xiao,
Yiteng Huang,
Liang Li,
Fuya Xin,
Luhua Xu,
Yuangui Zhang,
Zhicong Zeng,
Fengxia Lin,
Yong Jung Song
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s250524
Subject(s) - berberine , foam cell , infiltration (hvac) , inflammation , vulnerable plaque , damp , medicine , autophagy , pathological , chemistry , pharmacology , cholesterol , apoptosis , biochemistry , materials science , lipoprotein , physics , composite material , meteorology
Berberine (BBR) is an effective component of Huanglian and has shown to attenuate atherosclerosis (AS); however, the detailed mechanism of BBR-mediated protective actions against AS remains elusive. This study was undertaken to examine the effects of BBR on aortic atherosclerotic plaque stability and the expression of autophagy-related proteins in AS rats with damp-heat syndrome or yang deficiency.