Open Access<p>Activation of Cholinergic Anti-Inflammatory Pathway in Peripheral Immune Cells Involved in Therapeutic Actions of α-Mangostin on Collagen-Induced Arthritis in Rats</p>
Author(s) -
Qin Yin,
Youliang Wu,
Shu Pan,
Dandan Wang,
Meng-Qing Tao,
Weiya Pei,
Jian Zuo
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s249865
Subject(s) - immune system , peripheral blood mononuclear cell , cholinergic , in vivo , cytokine , immunology , arthritis , inflammation , ex vivo , medicine , chemistry , pharmacology , endocrinology , in vitro , biology , biochemistry , microbiology and biotechnology
Studies have shown that α-mangostin (MG) could exert anti-rheumatic effects in vivo by restoring immunity homeostasis, and have indicated that activation of the choline anti-inflammatory pathway (CAP) may contribute to this immunomodulatory property. The current study was designed to further investigate the effects of MG on the CAP in peripheral immune cells and clarify its relevance to the potential anti-rheumatic actions.