Open Access<p>Network Pharmacology and Experimental Evidence Reveal Dioscin Suppresses Proliferation, Invasion, and EMT via AKT/GSK3b/mTOR Signaling in Lung Adenocarcinoma</p>
Author(s) -
Wenli Mao,
Heng Yin,
Wenya Chen,
Tingxiu Zhao,
Shaofeng Wu,
Junqi He,
Baoheng Du,
YuHui Tan,
Ren Zhang,
Yanli He
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
ISSN - 1177-8881
DOI - 10.2147/dddt.s249651
Subject(s) - pi3k/akt/mtor pathway , protein kinase b , akt1 , epithelial–mesenchymal transition , cancer research , signal transduction , phosphorylation , chemistry , cell growth , kegg , adenocarcinoma , biology , cancer , medicine , downregulation and upregulation , biochemistry , gene expression , transcriptome , gene
Dioscin, a natural glycoside derived from many plants, has been proved to exert anti-cancer activity. Several studies have found that it reverses TGF-β1-induced epithelial-mesenchymal transition (EMT). Whether dioscin can reverse EMT by pathways other than TGF-β is still unknown.