Open Access<p>Inhibitory Effect of <em>Lygodium</em> Root on the Cytochrome P450 3A Enzyme in vitro and in vivo</p>
Author(s) -
Yunfang Zhou,
Ailian Hua,
Quan Zhou,
Peiwu Geng,
Feifei Chen,
Lianhe Yan,
Shuanghu Wang,
Congcong Wen
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s249308
Subject(s) - acacetin , apigenin , in vivo , pharmacology , chemistry , cytochrome p450 , luteolin , ic50 , in vitro , biochemistry , enzyme , biology , flavonoid , antioxidant , microbiology and biotechnology
The aim of the present study was to investigate the interactions of the main components of Lygodium root (ie, p-coumaric acid, acacetin, apigenin, buddleoside and Diosmetin-7-O-β-D-glucopyranoside) with cytochrome P450 3A enzyme activity both in vitro and in vivo.