Open Access<p>Pinocembrin Ameliorates Cognitive Impairment Induced by Vascular Dementia: Contribution of Reelin-dab1 Signaling Pathway</p>
Author(s) -
Zechun Kang,
Haigang Wang,
YuLin Yang,
Xiaoyue Zhao,
Qimeng Zhou,
Yinglin Yang,
Jingyu Yang,
Guanhua Du
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s249176
Subject(s) - reelin , vascular dementia , pinocembrin , medicine , dementia , cognitive impairment , dab1 , pharmacology , neuroscience , signal transduction , cognition , biology , psychiatry , genetics , receptor , biochemistry , disease , flavonoid , antioxidant
As a substrate of apoER2, Reelin has been verified to exert neuroprotection by preventing memory impairment. Pinocembrin is the most abundant natural flavonoid found in propolis, and it has been used to exert neuroprotection, blood-brain barrier protection, anti-oxidation, and inflammation diminishing, both in vitro and in vivo. However, the roles and molecular mechanisms of pinocembrin in neurobehavioral outcomes and neuronal repair after vascular dementia are still under investigation.