Open Access<p>Virtual Screening and Optimization of Novel mTOR Inhibitors for Radiosensitization of Hepatocellular Carcinoma</p>
Author(s) -
Yingqi Feng,
ShuangXi Gu,
Chen Yong-Shou,
Xudong Gao,
Yixin Ren,
Jianchao Chen,
Yinying Lu,
Heng Zhang,
Shuang Cao
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s249156
Subject(s) - pi3k/akt/mtor pathway , pharmacophore , hepatocellular carcinoma , cancer research , in vitro , radiation therapy , chemistry , pharmacology , medicine , biochemistry , signal transduction
Radiotherapy has an ameliorative effect on a wide variety of tumors, but hepatocellular carcinoma (HCC) is insensitive to this treatment. Overactivated mammalian target of rapamycin (mTOR) plays an important part in the resistance of HCC to radiotherapy; thus, mTOR inhibitors have potential as novel radiosensitizers to enhance the efficacy of radiotherapy for HCC.