Open Access<p>Suppression of Cisplatin-Induced Hepatic Injury in Rats Through Alarmin High-Mobility Group Box-1 Pathway by <em>Ganoderma lucidum</em>: Theoretical and Experimental Study</p>
Author(s) -
Hanan M. Hassan,
Lamya H. Al-Wahaibi,
Mohammad A. Elmorsy,
Yasmen F. Mahran
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s249093
Subject(s) - downregulation and upregulation , medicine , cisplatin , oxidative stress , liver injury , malondialdehyde , pharmacology , glutathione , gastroenterology , chemistry , chemotherapy , enzyme , biochemistry , gene
Drug-induced liver injury (DILI) is the most common cause of acute liver failure. The aim of this study was to investigate the molecular mechanisms by which Ganoderma lucidum mushroom (GLM) may ameliorate cisplatin (CP)-induced hepatotoxicity theoretically and experimentally.