Open Access<p>Sinomenine Attenuates Acetaminophen-Induced Acute Liver Injury by Decreasing Oxidative Stress and Inflammatory Response via Regulating TGF-β/Smad Pathway in vitro and in vivo</p>
Author(s) -
Hui Chen,
Yao Wang,
Fangzhou Jiao,
Fan Yang,
Xun Li,
Lu-Wen Wang
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s248823
Subject(s) - sinomenine , liver injury , oxidative stress , pharmacology , in vivo , acetaminophen , chemistry , alkaline phosphatase , apoptosis , alanine transaminase , medicine , biochemistry , biology , enzyme , microbiology and biotechnology
Liver disease is common and often life-threatening. Sinomenine (SIN) is an active ingredient extracted from Sinomenium acutum . This study investigated the protective effect and mechanism of sinomenine (SIN) on acetaminophen (APAP)-induced liver injury from in vitro and in vivo.