Open Access<p>Gastro-Protective Effects of Calycosin Against Precancerous Lesions of Gastric Carcinoma in Rats</p>
Author(s) -
Danyan Li,
Luqing Zhao,
Yuxin Li,
Xun Kang,
Shengsheng Zhang
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s247958
Subject(s) - calycosin , pathology , western blot , immunohistochemistry , cancer , gastric mucosa , h&e stain , medicine , chemistry , cancer research , stomach , biochemistry , daidzein , formononetin , genistein , gene
Gastric cancer is a leading cause of cancer death worldwide. In-depth research of precancerous lesions of gastric carcinoma (PLGC) with malignant transformation potential is a key measure to prevent the development of gastric carcinoma. Recently, calycosin has been shown to have anticancer effects in vitro and in vivo. The molecular mechanism by which calycosin affects PLGC, however, has not yet been elucidated. The purpose of this study was to evaluate the effect and mechanism of calycosin in N -methyl- N '-nitro- N -nitrosoguanidine (MNNG)-induced PLGC rats.