Open Access<p>Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling</p>
Author(s) -
Zhenming Gao,
Jidong Sui,
Rong Fan,
Weikun Qu,
Xuepeng Dong,
Da Sun
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s247103
Subject(s) - emodin , proinflammatory cytokine , inflammasome , bronchoalveolar lavage , medicine , pharmacology , pancreatitis , lung , chemistry , immunology , inflammation , biochemistry
Lung injury is a common complication of acute pancreatitis (AP), which leads to the development of acute respiratory distress syndrome and causes high mortality. In the present study, we investigated the therapeutic effect of emodin on AP-induced lung injury and explored the molecular mechanisms involved.