Open Access<p>Tanshinone IIA Ameliorates Progression of CAD Through Regulating Cardiac H9c2 Cells Proliferation and Apoptosis by miR-133a-3p/EGFR Axis</p>
Author(s) -
Hong Xu,
Haiqing Li,
Pengxiong Zhu,
Yun Liu,
Mei Zhou,
Anqing Chen
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
ISSN - 1177-8881
DOI - 10.2147/dddt.s245970
Subject(s) - apoptosis , cell growth , downregulation and upregulation , flow cytometry , tunel assay , microrna , cancer research , western blot , cell , epidermal growth factor receptor , microbiology and biotechnology , reporter gene , chemistry , medicine , biology , receptor , gene expression , gene , biochemistry
Coronary artery disease (CAD) leads to the highest mortality worldwide, seriously threatening human health. Tanshinone IIA (Tan IIA), which could be extracted from Danshen, is applied in the treatment of cardiovascular and cerebrovascular diseases. MicroRNAs (miRNAs, miRs) play pivotal roles in cell proliferation and cell apoptosis of the cardiovascular system. The aim of the present study was to explore the role of Tan IIA in CAD in vitro and the underlying molecular mechanism.