Open Access<p>Emodin Retarded Renal Fibrosis Through Regulating HGF and TGFβ–Smad Signaling Pathway</p>
Author(s) -
Fan Yang,
Lu Deng,
Jinpeng Li,
MuHu Chen,
Ying Li,
YingChun Hu,
Zhong Wang
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s245847
Subject(s) - emodin , smad , cancer research , fibrosis , in vivo , hepatocyte growth factor , medicine , western blot , kidney , chemistry , pharmacology , transforming growth factor , biology , receptor , biochemistry , gene , microbiology and biotechnology
Renal fibrosis is a frequently occurring type of chronic kidney disease that can cause end-stage renal disease. It has been verified that emodin or HGF can inhibit the development of renal fibrosis. However, the antifibrotic effect of emodin in combination with HGF remains unclear.