Open Access<p>LncRNA SNHG4 Attenuates Inflammatory Responses by Sponging miR-449c-5p and Up-Regulating STAT6 in Microglial During Cerebral Ischemia-Reperfusion Injury</p>
Author(s) -
Shuo Zhang,
Wenchong Sun,
Zuodi Liang,
Xiuru Yin,
Zhen-rong Ji,
Xiaohuan Chen,
Minjie Wei,
Lei Pei
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
ISSN - 1177-8881
DOI - 10.2147/dddt.s245445
Subject(s) - microglia , inflammation , ischemia , in vivo , medicine , luciferase , immunology , biology , cell culture , transfection , microbiology and biotechnology , genetics
Inflammatory response mediated by microglia plays a key role in cerebral ischemia-reperfusion injury. This study intends to probe the role of lncRNA SNHG4 in regulating the inflammatory response of the microglia during cerebral ischemia reperfusion.