Open Access<p>LncRNA PVT1 Suppresses the Progression of Renal Fibrosis via Inactivation of TGF-β Signaling Pathway</p>
Author(s) -
Liu Cao,
Peng Qin,
Jianjiang Zhang,
Huiju Qiao,
Peipei Shi,
Huyan Huo
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s245244
Subject(s) - gene knockdown , fibrosis , cancer research , kidney , downregulation and upregulation , pvt1 , in vivo , medicine , chemistry , biology , long non coding rna , cell culture , genetics , biochemistry , gene , microbiology and biotechnology
Renal fibrosis is a frequent pathway leading to end-stage kidney dysfunction. In addition, renal fibrosis is the ultimate manifestation of chronic kidney diseases (CKD). Long noncoding RNAs (lncRNAs) are known to be involved in occurrence of renal fibrosis, and lncRNA plasmacytoma variant translocation 1 (PVT1) has been reported to act as a key biomarker in renal diseases. However, the role of PVT1 in renal fibrosis remains unclear.