Open Access<p>Synthesis and Biological Evaluations of Monocarbonyl Curcumin Inspired Pyrazole Analogues as Potential Anti-Colon Cancer Agent</p>
Author(s) -
Zhen-Li Min,
Zhenggang Yue,
Xing Hong,
Zhenhai Yu,
Min Ye,
Qiong Yuan,
Xingjian Hu
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s244865
Subject(s) - curcumin , pyrazole , chemistry , apoptosis , clonogenic assay , cell cycle , cytotoxic t cell , mtt assay , cell growth , ic50 , cytotoxicity , cancer cell , western blot , biochemistry , cancer , cancer research , microbiology and biotechnology , stereochemistry , biology , in vitro , gene , genetics
The monocarbonyl analogs of curcumin (MCACs) have been widely studied for their promising antitumor activity. Pyrazole is a five-membered aromatic heterocyclic system with various bioactivities incorporated frequently in drugs. However, few of MCACs inspired pyrazole analogues were investigated. To search for more potent cytotoxic agents based on MCACs, a series of new 1,5-diaryl/heteroaryl-1,4-pentadien-3-ones inspired pyrazole moiety was synthesized and evaluated on their anti-colon cancer activities.