Open Access<p>High ACTN1 Is Associated with Poor Prognosis, and ACTN1 Silencing Suppresses Cell Proliferation and Metastasis in Oral Squamous Cell Carcinoma</p>
Author(s) -
Gaoqiang Xie,
Luodan Zhao,
Qiang Chen,
Dongxiao Tang,
Qiong-yu Chen,
Hongfei Lu,
Jiarong Cai,
Chen Zheng
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s244516
Subject(s) - cancer research , immunohistochemistry , metastasis , medicine , malignancy , cell cycle , flow cytometry , apoptosis , cell growth , gene knockdown , oncology , pathology , cancer , biology , immunology , biochemistry , genetics
Oral squamous cell carcinoma (OSCC) is a common malignancy of the oral cavity. As the survival rate of OSCC patients is low, it is crucial to explore new markers and therapeutic targets for early diagnosis of the disease. A high level of actinin alpha 1 (ACTN1) in patients could serve as an independent prognostic factor of acute myeloid leukemia. However, the role of ACTN1 in OSCC remains unclear. In the present study, we aimed to investigate the role of ACTN1 in OSCC.