Open Access<p>The NK-1R Antagonist Aprepitant Prevents LPS-Induced Oxidative Stress and Inflammation in RAW264.7 Macrophages</p>
Author(s) -
Xiaonan Zhao,
Zhan-Tao Bai,
Chenghua Li,
Chuanlun Sheng,
Hongyan Li
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s244099
Subject(s) - aprepitant , inflammation , oxidative stress , pharmacology , tachykinin receptor 1 , receptor antagonist , western blot , lipopolysaccharide , chemistry , proinflammatory cytokine , receptor , antagonist , immunology , biology , substance p , medicine , biochemistry , neuropeptide , vomiting , antiemetic , gene
The macrophage is one of the most important types of immune cells that protect against harmful stimuli. Macrophage activation plays a pivotal role in the progression and development of various inflammatory diseases. The neurokinin 1 receptor (NK-1R) is a G protein-coupled receptor that plays an important role in inflammatory diseases. Aprepitant is a kind of NK-1R antagonist. The purpose of this study is to determine the protective effect of aprepitant in lipopolysaccharide (LPS)-induced inflammatory responses in macrophages.