Open Access<p>In vitro Multistage Malaria Transmission Blocking Activity of Selected Malaria Box Compounds</p>
Author(s) -
Hamisi M. Malebo,
Sarah D’Alessandro,
Yehenew A Ebstie,
Soré Harouna,
Alain R Tenoh Guedoung,
Shaaban J Katani,
Silvia Parapini,
Donatella Taramelli,
Annette Habluetzel
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
ISSN - 1177-8881
DOI - 10.2147/dddt.s242883
Subject(s) - gametocyte , plasmodium falciparum , malaria , plasmodium berghei , biology , in vitro , parasite hosting , chloroquine , ic50 , plasmodium (life cycle) , pharmacology , virology , microbiology and biotechnology , biochemistry , immunology , world wide web , computer science
Continuous efforts into the discovery and development of new antimalarials are required to face the emerging resistance of the parasite to available treatments. Thus, new effective drugs, ideally able to inhibit the Plasmodium life-cycle stages that cause the disease as well as those responsible for its transmission, are needed. Eight compounds from the Medicines for Malaria Venture (MMV) Malaria Box, potentially interfering with the parasite polyamine biosynthesis were selected and assessed in vitro for activity against malaria transmissible stages, namely mature gametocytes and early sporogonic stages.