Open Access<p>A Comparative Study of Inhaled Nitric Oxide and an Intravenously Administered Nitric Oxide Donor in Acute Pulmonary Hypertension</p>
Author(s) -
Anna Stene Hurtsén,
Ilya Zorikhin Nilsson,
Emanuel M. Dogan,
Kristofer F. Nilsson
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s237477
Subject(s) - hypoxic pulmonary vasoconstriction , pulmonary hypertension , vascular resistance , medicine , nitric oxide , hypoxia (environmental) , vasodilation , blood pressure , anesthesia , vasoconstriction , pharmacology , cardiology , chemistry , oxygen , organic chemistry
Inhaled nitric oxide (iNO) selectively vasodilates the pulmonary circulation but the effects are sometimes insufficient. Available intravenous (iv) substances are non-selective and cause systemic side effects. The pulmonary and systemic effects of iNO and an iv mono-organic nitrite (PDNO) were compared in porcine models of acute pulmonary hypertension.