Open Access<p>Chlorogenic Acid Alleviates Aβ<sub>25-35</sub>-Induced Autophagy and Cognitive Impairment via the mTOR/TFEB Signaling Pathway</p>
Author(s) -
Lijuan Gao,
Xin Li,
Shi Meng,
Tengyun Ma,
Lihong Wan,
Shijun Xu
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s235969
Subject(s) - autophagy , pi3k/akt/mtor pathway , morris water navigation task , tfeb , atg5 , cathepsin d , neuroprotection , western blot , chemistry , cathepsin b , microbiology and biotechnology , pharmacology , biology , signal transduction , endocrinology , biochemistry , apoptosis , hippocampus , gene , enzyme
Chlorogenic acid (CGA), a phenolic acid isolated from fruits and vegetables, has been established to have neuroprotective properties in relation to Alzheimer's disease (AD). However, the precise mechanism by which CGA prevents cognitive deficits in AD has not been well studied. This study aimed to explore the potential molecular mechanism of CGA action using an Aβ 25-35- induced SH-SY5Y neuron injury and cogxnitive deficits model in APP/PS1 mice.