Open Access<p>Pharmacokinetics and Metabolism Research of Shenkang Injection in Rats Based on UHPLC-MS/MS and UHPLC-Q-Orbitrap HRMS</p>
Author(s) -
Xiaofang Jiang,
Lin Zhou,
Li Zuo,
Xiaohui Wang,
Yingying Shi,
Xiangdong Du,
Jun Zhang,
Liwei Liu,
Zhuolun Li,
Ling Xue,
Xin Liu,
Zhi Sun
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s235646
Subject(s) - chromatography , chemistry , formic acid , pharmacokinetics , selected reaction monitoring , electrospray ionization , analyte , liquid chromatography–mass spectrometry , tandem mass spectrometry , orbitrap , mass spectrometry , pharmacology , medicine
Shenkang injection, a traditional Chinese herbal prescription, had been widely used in renal disease due to its perfect curative effect. In this research, a novel, sensitive, accurate and rapid liquid chromatography-tandem mass spectrometric method was developed to simultaneously detect the seven active ingredients in rat plasma of Shenkang injection and investigate its pharmacokinetic behaviors with metabolism profiling meanwhile.