Open Access<p>Metformin Activates the AMPK-mTOR Pathway by Modulating lncRNA <em>TUG1</em> to Induce Autophagy and Inhibit Atherosclerosis</p>
Author(s) -
Ganhua You,
Xiangshu Long,
Fang Song,
Jing Huang,
Maobo Tian,
Xinfeng Yan,
Shiyan Deng,
Qiang Wu
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s233932
Subject(s) - metformin , autophagy , gene knockdown , ampk , pi3k/akt/mtor pathway , in vivo , downregulation and upregulation , small interfering rna , in vitro , pharmacology , chemistry , cancer research , transfection , medicine , signal transduction , biology , endocrinology , phosphorylation , apoptosis , protein kinase a , gene , biochemistry , diabetes mellitus , microbiology and biotechnology
Metformin has been shown to inhibit the proliferation and migration of vascular wall cells. However, the mechanism through which metformin acts on atherosclerosis (AS) via the long non-coding RNA taurine up-regulated gene 1 (lncRNA TUG1 ) is still unknown. Thus, this research investigated the effect of metformin and lncRNA TUG1 on AS.