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Metformin has been shown to inhibit the proliferation and migration of vascular wall cells. However, the mechanism through which metformin acts on atherosclerosis (AS) via the long non-coding RNA taurine up-regulated gene 1 (lncRNA TUG1 ) is still unknown. Thus, this research investigated the effect of metformin and lncRNA TUG1 on AS.

drug design development and therapy

&lt;p&gt;Metformin Activates the AMPK-mTOR Pathway by Modulating lncRNA &lt;em&gt;TUG1&lt;/em&gt; to Induce Autophagy and Inhibit Atherosclerosis&lt;/p&gt;