Open Access<p>PD98059 Protects Cerebral Cortex Mitochondrial Structure and Function at 48 h Post-Resuscitation in a Rat Model of Cardiac Arrest</p>
Author(s) -
Jin Zheng,
Menghua Chen,
Zhao-Yin Fu,
Nuo Li,
Lu Xie
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s231980
Subject(s) - resuscitation , mitochondrial permeability transition pore , mitochondrion , medicine , mptp , hypothermia , cerebral cortex , anesthesia , cardiopulmonary resuscitation , pharmacology , programmed cell death , endocrinology , chemistry , apoptosis , biochemistry , dopaminergic , dopamine
Mitochondria play a critical role as effectors and targets of brain injury in the post-resuscitation period. Although we found previously that the extracellular signal-regulated kinase (ERK)1/2 inhibitor PD98059 (PD) protects the brain against mitochondrial-mediated cell death at 24 h post-resuscitation in rats subjected to cardiac arrest/cardiopulmonary resuscitation (CA/CPR), it is not clear whether PD also exerts mitochondrial protective effect for a lasting time. Therefore, we examined the effect of PD on brain mitochondria at 48 h post-resuscitation to evaluate the time-effect of PD in the current study.