Open Access<p>NMMHC IIA Inhibition Ameliorates Cerebral Ischemic/Reperfusion-Induced Neuronal Apoptosis Through Caspase-3/ROCK1/MLC Pathway</p>
Author(s) -
Guangyun Wang,
Tiezheng Wang,
Yuanyuan Zhang,
Fang Li,
Boyang Yu,
Junping Kou
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s230882
Subject(s) - rock1 , neuroprotection , apoptosis , ischemia , microbiology and biotechnology , pharmacology , caspase 3 , medicine , chemistry , kinase , biology , protein kinase a , programmed cell death , biochemistry
Our previous studies have indicated that non-muscle myosin heavy chain IIA (NMMHC IIA) is involved in H 2 O 2 -induced neuronal apoptosis, which is associated with the positive feedback loop of caspase-3/ROCK1/MLC pathway. However, the neuroprotective effect of NMMHC IIA inhibition with an adeno-associated virus (AAV) vector after transient middle cerebral artery occlusion (MCAO) and its role in caspases-3/ROCK1/MLC pathway remain blurred.