Open Access<p>Sappanone A Protects Against Myocardial Ischemia Reperfusion Injury by Modulation of Nrf2</p>
Author(s) -
Xiaojing Shi,
Tao Gao,
Lili Ji,
Ge Tian
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s230358
Subject(s) - chemistry , oxidative stress , reactive oxygen species , reperfusion injury , apoptosis , terminal deoxynucleotidyl transferase , pharmacology , blot , antioxidant , phosphorylation , ischemia , biochemistry , microbiology and biotechnology , tunel assay , medicine , biology , gene
Oxidative stress is a major contributor to the onset and development of myocardial ischemia reperfusion injury (MIRI). Sappanone A (SA), a homoisoflavanone extracted from the heartwood of Caesalpinia sappan L ., has been demonstrated to possess powerful antioxidant activity. Therefore, this study aimed to determine the protective effect of SA on MIRI and investigate its underlying mechanism.