Open Access<p>Hyaluronic Acid Capped, Irinotecan and Gene Co-Loaded Lipid-Polymer Hybrid Nanocarrier-Based Combination Therapy Platform for Colorectal Cancer</p>
Author(s) -
Zhiyu Wang,
Aimin Zang,
Yuying Wei,
L. An,
Daojun Hong,
Yan Shi,
Jingnan Zhang,
Shenyong Su,
Guotao Fang
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s230306
Subject(s) - irinotecan , nanocarriers , in vivo , colorectal cancer , pharmacology , genetic enhancement , chemistry , combination therapy , cancer research , transfection , hyaluronic acid , cancer , medicine , drug , biology , biochemistry , gene , microbiology and biotechnology , anatomy
The current approach for treating colorectal cancer favors the use of drug and gene combination therapy, and targeted nano-systems are gaining considerable attention for minimizing toxicity and improving the efficacy of anticancer treatment. The aim of this study was to develop ligand-modified, irinotecan and gene co-loaded lipid-polymer hybrid nanocarriers for targeted colorectal cancer combination therapy.