Open Access<p>Dexmedetomidine Promotes Hippocampal Neurogenesis and Improves Spatial Learning and Memory in Neonatal Rats</p>
Author(s) -
Yahan Zhang,
Qiushi Gao,
Ziyi Wu,
Hang Xue,
Bo Liu,
Ping Zhao
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s228220
Subject(s) - neurogenesis , morris water navigation task , creb , hippocampal formation , hippocampus , open field , glial cell line derived neurotrophic factor , neuroscience , medicine , endocrinology , psychology , anesthesia , biology , neurotrophic factors , receptor , biochemistry , transcription factor , gene
Dexmedetomidine (Dex) is a highly selective α2-adrenoceptor agonist used as an off-label medication for pediatric sedation and analgesia. Recently, Dex was reported to exhibit neuroprotective efficacy in several brain injury models. Here we investigate whether neonatal Dex administration promotes hippocampal neurogenesis and enhances hippocampus-dependent spatial learning and memory under physiological conditions.