Open Access<p>Preparation of a Novel One-Armed Anti-c-Met Antibody with Antitumor Activity Against Hepatocellular Carcinoma</p>
Author(s) -
Yanxin Yin,
Jia Guo,
Fei Teng,
Lihua Yu,
Yun Jiang,
Kun Xie,
Ming Jiang,
Jianmin Fang
Publication year - 2019
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s224491
Subject(s) - c met , hepatocyte growth factor , antibody , hepatocellular carcinoma , cancer research , chemistry , protein kinase b , autocrine signalling , cell culture , cell growth , kinase , microbiology and biotechnology , signal transduction , medicine , biology , immunology , biochemistry , receptor , genetics
Antibody-based c-mesenchymal-epithelial transition factor (c-Met) inhibition is a promising strategy for hepatocellular carcinoma (HCC) treatment, but the intrinsic agonistic activity of the anti-c-Met antibody limits its application in drug development. Constructing a monovalent one-armed antibody has been reported to be an effective way to create an inhibitory anti-c-Met antibody.