Open Access<p>An Optimized Surfactant-Based PEG-PLCL In Situ Gel Formulation For Enhanced Activity Of Rosuvastatin In Poloxamer-Induced Hyperlipidemic Rats</p>
Author(s) -
Tarek A. Ahmed,
Mohammed A Mussari,
Seham El-Sayed Abdel-Hady,
Khalid M. El-Say
Publication year - 2019
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s224442
Subject(s) - pulmonary surfactant , chemistry , polyethylene glycol , peg 400 , rosuvastatin , chromatography , poloxamer , pharmacology , poloxamer 407 , peg ratio , drug , bioavailability , rosuvastatin calcium , medicine , biochemistry , organic chemistry , copolymer , finance , economics , polymer
Injectable in situ gel (ISG) systems suffer from high initial drug release that may result in toxic effects.