Open Access<p>Curcumin Attenuates Oxaliplatin-Induced Liver Injury and Oxidative Stress by Activating the Nrf2 Pathway</p>
Author(s) -
Yan-qing Lu,
ShengMing Wu,
BangDe Xiang,
LeQun Li,
Yandan Lin
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s224318
Subject(s) - curcumin , oxidative stress , oxaliplatin , pharmacology , chemistry , liver injury , keap1 , cancer research , medicine , biochemistry , colorectal cancer , cancer , transcription factor , gene
Oxaliplatin (OXA)-induced liver injury is one of the main limiting factors affecting the efficacy of OXA-based chemotherapy in patients with colorectal liver metastases. In addition, oxidative stress is an important pathophysiological mechanism of OXA-induced liver injury. Therefore, dietary antioxidants may decrease or prevent hepatic toxicity in vivo and be beneficial to OXA-based chemotherapy.