Open Access<p>1,25(OH)<sub>2</sub>D<sub>3</sub> Strengthens the Vasculogenesis of Multipotent Mesenchymal Stromal Cells from Rat Bone Marrow by Regulating the PI3K/AKT Pathway</p>
Author(s) -
Bozhi Ye,
Yawen Weng,
Shuang Lin,
Jiahui Lin,
Zhouqing Huang,
Weijian Huang,
Xueli Cai
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s222244
Subject(s) - mesenchymal stem cell , matrigel , chemistry , stromal cell , vasculogenesis , microbiology and biotechnology , pi3k/akt/mtor pathway , blot , biology , endothelial stem cell , cell , cancer research , signal transduction , biochemistry , gene , in vitro
Multipotent mesenchymal stromal cells (MSCs) have recently been reported to promote vasculogenesis by differentiating into endothelial cells and releasing numerous cytokines and paracrine factors. However, due to low cell activity, their potential for clinical application is not very satisfactory. This study aimed to explore the effects and mechanisms of 1,25-dihydroxyvitamin D (1,25(OH) 2 D 3 ) on the vasculogenesis of MSCs.