Open Access<p>Transformation of Meloxicam Containing Nanosuspension into Surfactant-Free Solid Compositions to Increase the Product Stability and Drug Bioavailability for Rapid Analgesia</p>
Author(s) -
András Gyovai,
Rita Ambrus,
Gábor Katona,
Tamás Sovány,
Róbert Gáspár,
Árpád Márki,
Eszter Ducza,
Anita Ivanov,
Ferenc Tömösi,
Tamás Janáky,
Piroska SzabóRévész
Publication year - 2019
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
ISSN - 1177-8881
DOI - 10.2147/dddt.s220876
Subject(s) - bioavailability , meloxicam , pulmonary surfactant , pharmacology , chemistry , drug , medicine , biochemistry
The aim of this work was to study the influence of solidification of meloxicam (Mel) containing nanosuspension (nanoMel) on the physical stability and drug bioavailability of the products. The nanoMel sample had poly(vinyl alcohol) (PVA) as a protective polymer, but no surfactant as a further stabilizing agent because the final aim was to produce surfactant-free solid phase products as well.