Open Access<p>Colon Targeting of Naringin for Enhanced Cytoprotection Against Indomethacin-Induced Colitis in Rabbits</p>
Author(s) -
Eman E. El Naggar,
Elham Abdelmonem Mohamed,
Thanaa Mohamed Borg,
Ahmed R. ElSheakh,
Mohamed F. Hamed
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s218357
Subject(s) - naringin , cytoprotection , colitis , pharmacology , medicine , chemistry , gastroenterology , oxidative stress , chromatography
Naringin is a promising anti-inflammatory drug against various disorders including ulcerative colitis. However, its oral bioavailability is low (8%) possibly due to cleavage at the upper gut. Consequently, colon targeting would be necessary for drug protection at the upper gut, enhanced oral bioavailability and potentiated cytoprotection against colitis.