Open Access<p>Design, Synthesis, And Evaluation Of Cyanopyridines As Anti-Colorectal Cancer Agents Via Inhibiting STAT3 Pathway</p>
Author(s) -
Linhao Xu,
Lingxi Shi,
Sensen Qiu,
Siyu Chen,
Mengsha Lin,
Youqun Xiang,
Chengguang Zhao,
Junfeng Zhu,
Liqun Shen,
Zhi-gui Zuo
Publication year - 2019
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s217800
Subject(s) - survivin , colorectal cancer , cancer research , stat3 , viability assay , western blot , cancer , cell culture , cell growth , chemistry , medicine , pharmacology , cell , biology , phosphorylation , biochemistry , gene , genetics
Colorectal cancer is one of the common malignant tumors. Cyanopyridine and aminocyanopyridine having a carbon-nitrogen bond have been shown to have significant anticancer effects. STAT3 is a promising therapeutic target in multiple cancers. However, there are currently no effective STAT3 inhibitors in clinical practice for the treatment of colorectal cancer.