Open Access<p>Glucoside Derivatives Of Podophyllotoxin: Synthesis, Physicochemical Properties, And Cytotoxicity</p>
Author(s) -
Cheng-Ting Zi,
Yang Liu,
Qinghua Kong,
Hongmei Li,
Xuebo Yang,
Ding Zhang,
ZiHua Jiang,
Jun Zhou
Publication year - 2019
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s215895
Subject(s) - podophyllotoxin , etoposide , cytotoxicity , chemistry , stereochemistry , cell culture , glucoside , acetylation , in vitro , pharmacology , biochemistry , biology , chemotherapy , medicine , genetics , alternative medicine , pathology , gene
Widespread concern of the side effects and the broad-spectrum anticancer property of podophyllotoxin as an antitumor agent highlight the need for the development of new podophyllotoxin derivatives. Although some per-butyrylated glucosides of podophyllotoxin and 4β-triazolyl-podophyllotoxin glycosides show good anticancer activity, the per-acetylated/free of podophyllotoxin glucosides and their per-acetylated are not well studied.