Open Access<p>Inhibition Of JNK Phosphorylation By Curcumin Analog C66 Protects LPS-Induced Acute Lung Injury</p>
Author(s) -
Zhifeng Xiao,
Fengli Xu,
Xiaonian Zhu,
Bin Bai,
L. Guo,
Guang Liang,
Xiaoou Shan,
Yali Zhang,
Yunjie Zhao,
Bing Zhang
Publication year - 2019
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s215712
Subject(s) - bronchoalveolar lavage , in vivo , inflammation , medicine , cytokine , curcumin , lipopolysaccharide , tumor necrosis factor alpha , pharmacology , in vitro , lung , immunology , chemistry , biology , biochemistry , microbiology and biotechnology
Acute lung injury (ALI) is characterized by high prevalence and high mortality. Thus far, no effective pharmacological treatment has been made for ALI in clinics. Inflammation is critical to the development of ALI. Curcumin analog C66, having reported as an inhibitor of c-Jun N-terminal kinase (JNK), exhibits anti-inflammatory property both in vitro and in vivo. However, whether C66 is capable of reducing lipopolysaccharide (LPS)-induced ALI through the inhibition of inflammation by targeting JNK remains unknown.