Open Access<p>Therapeutic potential of BLT1 antagonist for COPD: involvement of inducing autophagy and ameliorating inflammation</p>
Author(s) -
Li Zhang,
Jingwen Huang,
Ran Dong,
Yun Feng,
Min Zhou
Publication year - 2019
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s215433
Subject(s) - autophagy , inflammation , antagonist , copd , medicine , pharmacology , chemistry , receptor , apoptosis , biochemistry
Leukotriene B4 (LTB4) is a major pro-inflammatory mediator that leads to the persistence of chronic inflammation in chronic obstructive pulmonary disease (COPD). The purpose of this study was to evaluate therapeutic potential of BLT1 antagonist for cigarette smoke (CS)-induced COPD and to explore the underlying mechanism.