Open Access<p>Downregulation of p66Shc can reduce oxidative stress and apoptosis in oxidative stress model of marginal cells of stria vascularis in Sprague Dawley rats</p>
Author(s) -
Cong Hao,
Xuewen Wu,
Ruoyu Zhou,
Hao Zhang,
Yulai Zhou,
Xinxing Wang,
Yong Feng,
Lingyun Mei,
Chufeng He,
Xinzhang Cai,
Lisha Wu
Publication year - 2019
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s214918
Subject(s) - oxidative stress , reactive oxygen species , gene knockdown , microbiology and biotechnology , chemistry , apoptosis , downregulation and upregulation , biology , biochemistry , gene
p66Shc, a Src homologue and collagen homologue (Shc) adaptor protein, mediates oxidative stress signaling. The p66Shc-null mice have increased lifespan and enhanced resistance to oxidative stress. Studies have also indicated its potential role in inner ear aging, which can lead to deafness.