Open Access<p>Structural Insight into the Mechanism of 4-Aminoquinolines Selectivity for the alpha2A-Adrenoceptor</p>
Author(s) -
Zaibing Li,
Jingyu Li,
Liyan Liu,
Wenyi Deng,
Qingrong Liu,
Ruofan Liu,
Wen Zhang,
Zaiqing He,
Lei Fan,
Yingzhuo Yang,
YunBo Duan,
Huifang Hou,
Xinyuan Wang,
Zhimei Yang,
Xiaoying Wang,
Shanze Chen,
Yi Wang,
Ning Huang,
Junli Chen
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
ISSN - 1177-8881
DOI - 10.2147/dddt.s214157
Subject(s) - aminoquinolines , selectivity , mechanism (biology) , chemistry , stereochemistry , combinatorial chemistry , biochemistry , physics , catalysis , quantum mechanics
α 2A -adrenoceptor (AR) is a potential target for the treatment of degenerative diseases of the central nervous system, and α 2A -AR agonists are effective drugs for this condition. However, the lack of high selectivity for α 2A -AR subtype of traditional drugs greatly limits their clinic usage.