Open Access<p>The safety, pharmacodynamics, and pharmacokinetics of immediate-release formulation containing esomeprazole 20 mg/sodium bicarbonate 800 mg in healthy adult male</p>
Author(s) -
Dasohm Kim,
Min Soo Park,
Byung Won Yoo,
Tae Kyung Hong,
Shin Jung Park,
Choon Ok Kim
Publication year - 2019
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s212491
Subject(s) - esomeprazole , pharmacodynamics , pharmacokinetics , sodium bicarbonate , crossover study , pharmacology , dosing , medicine , enteric coating , adverse effect , chemistry , dosage form , placebo , alternative medicine , pathology
Esomeprazole is the most effective treatment for acid-related disorders and is widely used with enteric coating due to rapid degradation in the acidic environment. However, the enteric-coated formulation delays absorption and onset of action. To overcome this limitation, an immediate-release formulation containing esomeprazole 20 mg and sodium bicarbonate 800 mg (IR-ESO) was developed.