Open Access<p>Exosomes Derived From Bone Marrow Mesenchymal Stem Cells Inhibit Complement Activation In Rats With Spinal Cord Injury</p>
Author(s) -
Chuanliang Zhao,
Xin Zhou,
Jie Qiu,
Danqing Xin,
Tingting Li,
Xili Chu,
Hongtao Yuan,
Haifeng Wang,
Zhen Wang,
Dachuan Wang
Publication year - 2019
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s209636
Subject(s) - western blot , spinal cord injury , mesenchymal stem cell , microvesicles , complement system , microglia , spinal cord , bone marrow , medicine , microbiology and biotechnology , chemistry , immunology , pathology , inflammation , biology , antibody , microrna , biochemistry , psychiatry , gene
Spinal cord injury (SCI) is a relatively common, devastating traumatic condition resulting in permanent disability. In this study, the use of exosomes derived from bone mesenchymal stem cells (BMSCs-Exo) as a cell-free therapy for the treatment of SCI in rats was investigated to gain insights into their mechanisms of action.