Open Access<p>Arsenic sulfide induces miR-4665-3p to inhibit gastric cancer cell invasion and migration</p>
Author(s) -
Xiuli Zhang,
Zhen Tan,
Ting Kang,
Chuangying Zhu,
Siyu Chen
Publication year - 2019
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s209219
Subject(s) - arsenic , cancer research , chemistry , cancer , cell , biology , biochemistry , genetics , organic chemistry
Gastric carcinogenesis is a multistep process and is the second-highest cause of cancer death worldwide with a high incidence of invasion and metastasis. MicroRNAs (miRNAs) engage in complex interactions with the machinery that controls the transcriptome and concurrently target multiple mRNAs. Recent evidence has shown that miRNAs are involved in the cancer progression, including promoting cell-cycle, conferring resistance to apoptosis, and enhancing invasiveness and metastasis. Here, we aim to elucidate the roles of miRNAs, especially microRNA-4665-3p (miR-4665-3p), in the inhibitory effect of arsenic sulfide in gastric cancer (GC).