Open Access<p>Effects of losartan and atorvastatin on the development of early posttraumatic joint stiffness in a rat model</p>
Author(s) -
Andreas Baranowski,
Ludwig Schlemmer,
Katharina Förster,
Ekaterina Slotina,
Tim Mickan,
Sebastian Truffel,
Anja Klein,
Stefan G. Mattyasovszky,
Alexander Hofmann,
Ulrike Ritz,
Pol Maria Rommens
Publication year - 2019
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s204135
Subject(s) - losartan , atorvastatin , joint (building) , medicine , joint stiffness , endocrinology , urology , pharmacology , stiffness , receptor , angiotensin ii , structural engineering , engineering
After a trauma, exuberant tissue healing with fibrosis of the joint capsule can lead to posttraumatic joint stiffness (PTJS). Losartan and atorvastatin have both shown their antifibrotic effects in different organ systems.