Open Access<p>Dexmedetomidine attenuates the neurotoxicity of propofol toward primary hippocampal neurons in vitro via Erk1/2/CREB/BDNF signaling pathways</p>
Author(s) -
Youbing Tu,
Yubing Liang,
Yong Xiao,
Jing Lv,
Ruicong Guan,
Fei Xiao,
Yubo Xie,
Qiang Xiao
Publication year - 2019
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s188436
Subject(s) - creb , dexmedetomidine , viability assay , neuroprotection , hippocampal formation , pharmacology , apoptosis , chemistry , medicine , endocrinology , biochemistry , transcription factor , sedation , gene
Propofol is a commonly used general anesthetic for the induction and maintenance of anesthesia and critical care sedation in children, which may add risk to poor neurodevelopmental outcome. We aimed to evaluate the effect of propofol toward primary hippocampal neurons in vitro and the possibly neuroprotective effect of dexmedetomidine pretreatment, as well as the underlying mechanism.